PHYSIOLOGY AND PATHOPHYSIOLOGY OF PROTEINASE-ACTIVATED RECEPTORS (PARS): PAR-2 AS A POTENTIAL THERAPEUTIC TARGET

Physiology and Pathophysiology of Proteinase-Activated Receptors (PARs): PAR-2 as a Potential Therapeutic Target

PAR-2 is the second member of the family of proteinase-activated receptors activated by trypsin, tryptase, and several other serine proteinases.In order to evaluate the therapeutic potential for PAR-2, we have performed studies on PAR-2-mediated signal transduction and investigated the dale duby obsidian knives effects of PAR-2 gene deficiency in d

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Effect of Reactive Oxygen Species on the Endoplasmic Reticulum and Mitochondria during Intracellular Pathogen Infection of Mammalian Cells

Oxidative stress, particularly reactive oxygen species (ROS), are important for innate immunity against pathogens.ROS directly attack pathogens, regulate and amplify immune signals, induce autophagy and activate inflammation.In addition, production of ROS by pathogens affects the endoplasmic reticulum (ER) dale duby obsidian knives and mitochondria

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